List of Validated Methods
No.;Analyte;Method;LLOQ (ng/mL);Note
1;11-Deoxycortisol;HPLC/MS/MS;0,02;determination of endogenous levels in postmenopausal women
2;17-Carboxybudesonide;HPLC/MS/MS;0,1;in dog plasma
3;17-Deacetylnorgestimate;HPLC/MS/MS;0,02;
4;17-Hydroxyprogesterone;HPLC/MS/MS;0,02;determination of endogenous levels in postmenopausal women
5;1-Adamantylethyloxy-3-morpholino-2-propanol;HPLC/MS/MS;0,05;
6;2-Hydroxymethylmetronidazole;HPLC/MS/MS;4;
7;5'-Deoxy-5-fluorocytidine;HPLC/MS/MS;25;
8;5'-Deoxy-5-fluorouridine;HPLC/MS/MS;25;
9;5-Fluorouracil;HPLC/MS/MS;5;
10;5-Hydroxymethyltolterodine;HPLC/MS/MS;0,05;
11;5-Hydroxypropafenone;HPLC/MS/MS;0,5;
12;9-Hydroxyrisperidone;HPLC/MS/MS;0,1;
13;Abiraterone;HPLC/MS/MS;0,2;
14;AcetaminophenК(paracetamol);HPLC/MS/MS;250;
15;Acetazolamide;HPLC/MS/MS;250;
16;Acetylcysteine;HPLC/MS/MS;50;
17;Acetylsalicylic acid;HPLC/MS/MS;25;common method with salicylic acid
18;Acetylsalicylic acid;HPLC/MS/MS;5;common method with salicylic acid
19;Aciclovir;HPLC;15;
20;Aciclovir;HPLC/MS/MS;5;
21;Agomelatine;HPLC/MS/MS;0,1;
22;Aldosterone;HPLC/MS/MS;0,01;determination of endogenous levels in postmenopausal women
23;Alendronate;HPLC/MS/MS;0,75;
24;Amlodipine;HPLC/MS/MS;0,1;
25;Amlodipine;HPLC/MS/MS;0,5;rat plasma direct injection
26;Amlodipine;chiral HPLC/MS/MS;0,2;
27;Amoxicillin;HPLC/MS/MS;100;
28;Anagrelide;HPLC/MS/MS;0,075;
29;Anastrozole;HPLC/MS/MS;0,5;
30;Androstenedione;HPLC/MS/MS;0,02;determination of endogenous levels in postmenopausal women
31;Aripiprazene;HPLC/MS/MS;0,1;
32;Aripiprazole;HPLC/MS/MS;0,4;
33;Atomoxetine;HPLC/MS/MS;5;
34;Atorvastatin;HPLC/MS/MS;0,8;common method with ezetimibe
35;Atorvastatin;HPLC/MS/MS;0,5;
36;Atorvastatin;HPLC/MS/MS;0,25;common method with Ezetimibe and Ezetimibe Glucuronide
37;Azithromycin;HPLC/MS/MS;4;
38;Bendroflumethiazide;HPLC/MS/MS;0,4;
39;Bicalutamide;chiral HPLC/MS/MS;1;
40;Bicalutamide;HPLC/MS/MS;2;
41;Bisoprolol;HPLC/MS/MS;0,5;
42;Bosentan;HPLC/MS/MS;5;
43;Budesonide;HPLC/MS/MS;0,05;in dog plasma
44;Bumetanide;HPLC;4;
45;Caffeine;HPLC/MS/MS;100;common method with paraxantine
46;Candesartan;HPLC/MS/MS;2;
47;Capecitabine;HPLC/MS/MS;100;
48;CaptoprilК(free);HPLC/MS/MS;1;
49;CaptoprilК(free);HPLC;15;
50;Carbamazepine;HPLC;25;
51;Carbocisteine;HPLC/MS/MS;50;
52;Carvedilol;HPLC/MS/MS;1;
53;Carvedilol metabolite M IV;HPLC/MS/MS;0,2;
54;Cefditoren;HPLC/MS/MS;50;
55;Cefixime;HPLC/MS/MS;100;
56;Cefprozil;HPLC/MS/MS;100;
57;Cefuroxime;HPLC/MS/MS;50;
58;Celecoxib;HPLC/MS/MS;10;
59;Chlorambucil;HPLC/MS/MS;1;
60;Chlorthalidone;HPLC/MS/MS;2;
61;Cilostazol;HPLC/MS/MS;50;
62;Ciprofloxacine;HPLC/MS/MS;50;
63;Clarithromycin;HPLC/MS/MS;50;
64;Clobazam;HPLC/MS/MS;1;
65;Clozapin;GC/MS;0,6;
66;C-peptide;ELISA;0,2;
67;Dapagliflozin;HPLC/MS/MS;2;common method with linagliptin
68;Darunavir;HPLC/MS/MS;200;
69;Dasatinib;HPLC/MS/MS;0,25;
70;Desethyloxybutynin;GC/MS;2;
71;Desethyloxybutynin;HPLC;4;
72;Desloratadine;HPLC/MS/MS;0,05;
73;Desmethylfluoxetine;GC/MS;0,4;
74;Dexamethasone;HPLC/MS/MS;0,25;
75;Dexketoprofen;HPLC/MS/MS;50;
76;Dextromethorphan;HPLC/MS/MS;0,01;
77;Diclofenac;HPLC/MS/MS;5;
78;Didanosine;HPLC/MS/MS;20;
79;Dienogest;HPLC/MS/MS;1;
80;Diosmetin-3-O-glucuronide;HPLC/MS/MS;0,05;
81;Donepezil;HPLC/MS/MS;0,2;
82;Doxazosin;HPLC;0,4;
83;Doxylamine;HPLC/MS/MS;;
84;Drospirenone;HPLC/MS/MS;0,5;
85;Drotaverine;HPLC/MS/MS;3;
86;Duloxetine;HPLC/MS/MS;0,5;
87;Dutasteride;HPLC/MS/MS;0,05;
88;Emoxipine;HPLC/MS/MS;5;
89;Enalapril;HPLC/MS/MS;1;
90;Enalaprilat;HPLC/MS/MS;1,2;
91;Entecavir;HPLC/MS/MS;0,05;
92;Eplerenon;HPLC/MS/MS;10;
93;Epoxycarbamazepin;HPLC;25;
94;Erlotinib;HPLC/MS/MS;5;
95;Escitalopram;HPLC/MS/MS;0,25;
96;Esomeprazole;HPLC/MS/MS;10;
97;Estradiol;HPLC/MS/MS;0,0008;determination of endogenous levels in postmenopausal women
98;Estrone;HPLC/MS/MS;0,001;determination of endogenous levels in postmenopausal women
99;Estrone sulfate;HPLC/MS/MS;0,01;determination of endogenous levels in postmenopausal women
100;Eszopiclon;HPLC/MS/MS;0,25;
101;Ethinylestradiol;HPLC/MS/MS;0,001;
102;Ethylmethylhydroxypyridine;HPLC/MS/MS;0,25;
103;Ethylmethylhydroxypyridine;HPLC/MS/MS;1;
104;Etoricoxib;HPLC/MS/MS;5;
105;Everolimus;HPLC/MS/MS;1;in whole blood
106;Exemestane;HPLC/MS/MS;0,25;
107;Ezetimibe;HPLC/MS/MS;0,04;common method with ezetimibe glucuronide
108;Ezetimibe;HPLC/MS/MS;0,08;common method with atorvastatin
109;Ezetimibe;HPLC/MS/MS;0,05;common method with simvastatin
110;Ezetimibe;HPLC/MS/MS;0,05;common method with atorvastatin and ezetimibe glucuronide
111;Ezetimibe glucuronide;HPLC/MS/MS;1;common method with atorvastarin and ezetimibe
112;Ezetimibe glucuronide;HPLC/MS/MS;0,8;common method with ezetimibe
113;Ezetimibe glucuronide;HPLC/MS/MS;0,8;common method with atorvastatin
114;Famotidine;HPLC;2,5;
115;Fenpiverinium;HPLC/MS/MS;0,03;common method with ketorolac and pitofenone
116;Fenspiride;HPLC/MS/MS;1;
117;Fenspiride;HPLC/MS/MS;1;
118;Fingolimod;HPLC/MS/MS;0,01;in whole blood
119;Fluoxetine;GC/MS;0,4;
120;Flupirtine;HPLC/MS/MS;20;
121;Flupirtine;HPLC/MS/MS;10;
122;Flurbiprofen;HPLC/MS/MS;100;
123;Fluvoxamine;HPLC;1,5;
124;Fosfomycin;HPLC/MS/MS;500;
125;Fulvestrant;HPLC/MS/MS;0,2;
126;FuraginК(Furazidine);HPLC/MS/MS;2;
127;FuraginК(Furazidine);HPLC/MS/MS;100;
128;Ganciclovir;HPLC/MS/MS;50;
129;Gentamicin;HPLC/MS/MS;;in animals samples
130;Glargine;ELISA;7,5 µU/mL;
131;Gliclazide;HPLC/MS/MS;20;
132;Glimepiride;HPLC/MS/MS;1;
133;Glucosamine;HPLC/MS/MS;10;
134;Glycoursodeoxycholic acid;HPLC/MS/MS;20;endogenous compound
135;Hydrochlorothiazide;HPLC/MS/MS;0,2;
136;Hydrochlorothiazide;HPLC/MS/MS;0,5;
137;Hydrocortisone;HPLC/MS/MS;10;endogenous compound
138;Hydroxyurea;HPLC/MS/MS;250;
139;Ibuprofen;HPLC/MS/MS;500;
140;Ibuprofen;HPLC/MS/MS;250;
141;IsoprinosineК(DIP);HPLC/MS/MS;10;
142;IsoprinosineК(PAcBA);HPLC/MS/MS;50;
143;Imatinib;HPLC/MS/MS;20;
144;Indapamide;HPLC/MS/MS;1;in whole blood
145;Insulin;ELISA;6,25 µU/mL;
146;Insulin;ELISA;12,5 µU/mL;
147;Insulin;ELISA;4 µU/mL;
148;Ipidacrine;HPLC/MS/MS;0,1;
149;Irbesartan;HPLC/MS/MS;5;
150;IsoprinosineК(DIP);HPLC/MS/MS;80;
151;IsoprinosineК(PAcBA);HPLC/MS/MS;200;
152;Ivabradine;HPLC/MS/MS;0,25;
153;Ketorolac;HPLC/MS/MS;3;common method with fenpiverinium and pitofenone
154;Ketorolac;HPLC/MS/MS;30;
155;Lacidipine;HPLC/MS/MS;0,02;
156;Lenalidomide;HPLC/MS/MS;2;
157;Letrozole;HPLC/MS/MS;0,5;
158;Letrozole;HPLC/MS/MS;1;
159;Levetiracetam;HPLC/MS/MS;200;
160;Levocetirizine;HPLC/MS/MS;2,5;
161;Levocetirizine;HPLC/MS/MS;1;common method with montelucast
162;Levofloxacine;HPLC/MS/MS;100;
163;Levothyroxine;HPLC/MS/MS;10;endogenous compound
164;Linagliptin;HPLC/MS/MS;0,1;common method with dapagliflozin
165;Linezolid;HPLC/MS/MS;200;
166;Liothyronine;HPLC/MS/MS;0,25;endogenous compound
167;Lisinopril;HPLC/MS/MS;1;
168;Lornoxicam;HPLC/MS/MS;20;
169;Losartan;HPLC/MS/MS;3;
170;Lovastatin;GC/MS/MS;0,15;
171;Lovastatin hydroxyacid;GC/MS/MS;0,15;
172;Mebeverine acid;HPLC/MS/MS;10;
173;Mebeverine acid, desmethyl;HPLC/MS/MS;10;
174;Megestrol acetate;HPLC/MS/MS;1;
175;Meldonium;HPLC/MS/MS;100;
176;Meloxicam;HPLC;30;
177;Meloxicam;HPLC/MS/MS;20;
178;Memantine;HPLC/MS/MS;0,2;
179;Metformin;HPLC/MS/MS;10;
180;Methyldopa;HPLC/MS/MS;20;
181;MethylsulfoxyethanolК(MSE);HPLC/MS/MS;200;
182;Metoprolol;HPLC/MS/MS;1;
183;Metronidazole;HPLC/MS/MS;20;
184;Mianserin;chiral HPLC/MS/MS;0,2;
185;Micophenolic acid;HPLC/MS/MS;500;
186;Mildronate;HPLC/MS/MS;50;
187;Milnacipran;HPLC/MS/MS;2;
188;Misoprostol acid;HPLC/MS/MS;0,05;
189;Misoprostol acid;HPLC/MS/MS;0,025;
190;Moclobemide;HPLC;30;
191;Montelukast;HPLC/MS/MS;1;
192;Montelukast;HPLC/MS/MS;2;common method with levocetirizine
193;Moxifloxacin;HPLC/MS/MS;50;
194;Moxonidine;HPLC/MS/MS;0,02;
195;N,N-Didesmethyl Sibutramine;HPLC/MS/MS;0,1;common method with N-desmethyl sibutramine and sibutramine
196;N-Desmethyl Sibutramine;HPLC/MS/MS;0,1;common method with N,N-Didesmethyl sibutramine and sibutramine
197;Naftidrofuryl;HPLC;200;
198;Naproxen;HPLC/MS/MS;200;
199;Naproxen;HPLC/MS/MS;10;in urine
200;Naproxen;HPLC/MS/MS;500;
201;Nebivolol;HPLC/MS/MS;0,02;
202;Nerofe;HPLC/MS/MS;1 000,00;in dog plasma
203;Nevirapine;HPLC/MS/MS;25;
204;Nitrofurantoin;HPLC/MS/MS;2;
205;Norgestimate;HPLC/MS/MS;0,0004;
206;O-desmethyltramadol;HPLC/MS/MS;0,5;
207;O-desmethylvenlafaxine;HPLC/MS/MS;0,5;
208;O-hydroxy atorvastatin;HPLC/MS/MS;0,4;common method with ezetimibe
209;Olanzapine;HPLC/MS/MS;0,1;
210;Olanzapine;HPLC/MS/MS;0,25;
211;Olmesartan;HPLC/MS/MS;10;
212;Omeprazole;HPLC/MS/MS;10;
213;Ondansetron;HPLC/MS/MS;1;
214;Oracin;HPLC;20;
215;Ornidazole;HPLC/MS/MS;200;
216;Oseltamivir;HPLC/MS/MS;0,5;
217;Oxybutynin;GC/MS;0,2;
218;Paliperidon;HPLC/MS/MS;0,2;
219;Paraxantine;HPLC/MS/MS;100;common method with caffeine
220;Paroxetine;HPLC/MS/MS;0,1;
221;Paroxetine;HPLC/MS/MS;0,025;
222;Paroxetine metabolite;HPLC/MS/MS;0,2;
223;Pentoxifylline;HPLC/MS/MS;1;
224;Pentoxifylline metabolite M1;HPLC/MS/MS;2;
225;Pentoxifylline metabolite M5;HPLC/MS/MS;10;
226;Perindopril;HPLC/MS/MS;2,5;
227;Perindoprilate;HPLC/MS/MS;0,25;
228;p-hydroxy atorvastatin;HPLC/MS/MS;0,04;common method with ezetimibe
229;Pioglitazone;HPLC/MS/MS;10;
230;Pioglitazone metabolite M IV;HPLC/MS/MS;5;
231;Piracetam;HPLC/MS/MS;500;
232;Pitofenone;HPLC/MS/MS;1;common method with ketorolac and fenpiverinium
233;Pizotifen;GC/MS/MS;0,05;
234;Pramipexole;HPLC/MS/MS;0,02;
235;Pramipexole;HPLC/MS/MS;0,01;
236;Prednisolone;HPLC/MS/MS;3;
237;Pregabalin;HPLC/MS/MS;50;
238;Pridinol;HPLC/MS/MS;0,2;
239;Pridinol;HPLC/MS/MS;1;in urine
240;Propafenone;HPLC/MS/MS;1;
241;Propiverine;HPLC/MS/MS;0,5;
242;Quetiapine;HPLC/MS/MS;1;
243;Raloxifene;HPLC/MS/MS;0,01;
244;Raloxifene-4-glucoronide;HPLC/MS/MS;1;
245;Raloxifene-6-glucoronide;HPLC/MS/MS;0,5;
246;Ramipril;HPLC/MS/MS;0,2;
247;Ramipril;HPLC/MS/MS;0,4;
248;Ramipril;HPLC/MS/MS;0,05;in dog plasma
249;Ramiprilate;HPLC/MS/MS;0,2;
250;Ramiprilate;HPLC/MS/MS;0,5;in dog plasma
251;Ranitidin;HPLC;10;
252;Ranolazine;HPLC/MS/MS;25;
253;Rasagiline;HPLC/MS/MS;0,1;
254;Rebamipide;HPLC/MS/MS;4;
255;Ribavirin;HPLC/MS/MS;3;
256;Risperidone;HPLC/MS/MS;0,1;
257;Ritonavir;HPLC/MS/MS;20;
258;Rizatriptan;HPLC/MS/MS;0,1;
259;Ropinirole;HPLC/MS/MS;0,1;
260;Rosuvastatin;HPLC/MS/MS;0,05;
261;Salicylic acid;HPLC;200;
262;Salicylic acid;HPLC/MS/MS;100;common method with acetylsalicylic acid
263;Salicylic acid;HPLC/MS/MS;20;common method with acetylsalicylic acid
264;Sibutramine;HPLC/MS/MS;0,1;common method with N,N-didesmethyl sibutramine and N-desmethyl sibutramine
265;Sildenafil;HPLC/MS/MS;1;
266;Sildenafil;HPLC/MS/MS;5;
267;Simvastatin;GC/MS/MS;0,5;
268;Simvastatin;LC/MS/MS;0,5;
269;Simvastatin;LC/MS/MS;0,2;common method with ezetimibe
270;Simvastatin;LC/MS/MS;0,2;
271;Simvastatin hydroxyacid;GC/MS/MS;0,1;
272;Simvastatin hydroxyacid;LC/MS/MS;0,1;
273;Simvastatin hydroxyacid;LC/MS/MS;0,05;common method with ezetimibe
274;Sitagliptin;HPLC/MS/MS;1;
275;Solifenacin;HPLC/MS/MS;0,2;
276;Tadalafil;HPLC/MS/MS;5;
277;Tamsulosin;HPLC/MS/MS;0,2;
278;Tamsulosin;HPLC/MS/MS;0,1;
279;Tamsulosin;HPLC/MS/MS;0,05;
280;Tauroursodeoxycholic acid;HPLC/MS/MS;5;endogenous compound
281;Telmisartan;HPLC/MS/MS;2;
282;Tenofovir;HPLC/MS/MS;5;
283;Terbinafine;HPLC;20;
284;Thiocolchicoside metabolite M1;HPLC/MS/MS;1;
285;Tianeptine;chiral HPLC/MS/MS;2;
286;Ticagrelor;HPLC/MS/MS;5;
287;Tiotropium;HPLC/MS/MS;0,0001;
288;Tolperisone;HPLC/MS/MS;0,5;
289;Tolterodine;HPLC/MS/MS;0,05;
290;Torasemide;HPLC/MS/MS;20;
291;Toremifene;HPLC/MS/MS;2;
292;Tramadol;GC/MS;6;
293;Tramadol;HPLC/MS/MS;5;
294;Trimetazidine;HPLC/MS/MS;0,5;
295;Ulipristal;HPLC/MS/MS;0,2;
296;Uridine;HPLC/MS/MS;150;endogenous compound
297;Ursodeoxycholic acid;HPLC/MS/MS;10;endogenous compound
298;Valganciclovir;HPLC/MS/MS;5;
299;Valproic acid;HPLC/MS/MS;250;
300;Valsartan;HPLC/MS/MS;50;
301;Vardenafil;HPLC/MS/MS;0,25;
302;Venlafaxine;HPLC/MS/MS;10;in rat plasma
303;Venlafaxine;HPLC/MS/MS;0,5;
304;Vildagliptin;HPLC/MS/MS;2;
305;Voriconazole;HPLC/MS/MS;5;
306;Warfarin;HPLC;20;
307;Zidovudine;HPLC/MS/MS;25;
308;Zolpidem;HPLC;1;plasma direct injection
309;Zopiclon;HPLC;4;
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